In silico analyzing the molecular interactions of plant-derived inhibitors against E6AP, p53, and c-Myc binding sites of HPV type 16 E6 oncoprotein.
Farzan Nabati, Mohammad Moradi, Hassan Mohabatkar
Abstract
), Hypericin and Apigetrin) were probably used as the possible source of cancer treatment caused by E6 oncoprotein. In this research, we conducted the docking calculations by Autodock 4.2.6 software. Docking analysis showed the interaction of these plant-originated inhibitors with E6AP, p53, and Myc binding sites on the E6 oncoprotein which support the normal function of E6AP, p53, and Myc.
Topics & Concepts
AutoDockADMEIn silicoPubChemDocking (animal)CarcinogenBiologyCancerPharmacologyComputational biologyCancer researchBiochemistryPharmacokineticsMedicineGeneticsGeneNursingCervical Cancer and HPV ResearchHerpesvirus Infections and TreatmentsHepatitis B Virus Studies