Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana
Yaw Aniweh, Alamissa Soulama, Jersley D. Chirawurah, Felix Ansah, Harry Danwonno, Fanta Sogore, Mélanie Rouillier, Brice Campo, Lucas Amenga–Etego, Abdoulaye Djimdé, Gordon A. Awandare, Laurent Dembélé
Abstract
Current malaria control and elimination tools such as drug treatments are not specifically targeting P.ovale . P. ovale can form hypnozoite and cause relapsing malaria. P. ovale is the third most dominant species in Africa and requires radical cure treatment given that it can form liver dormant forms called hypnozoites that escape all safe treatments. The inappropriate treatment of P. ovale would sustain its transmission in Africa where the medical need is the greatest.
Topics & Concepts
Plasmodium ovalePlasmodium falciparumMalariaChloroquinePharmacologyPrimaquineMedicineArtesunateQuinineBiologyVirologyImmunologyPlasmodium vivaxMalaria Research and ControlTrypanosoma species research and implicationsResearch on Leishmaniasis Studies