Alpelisib administration reduced lymphatic malformations in a mouse model and in patients
Florence Delestre, Quitterie Venot, Charles Bayard, Antoine Fraissenon, Sophia Ladraa, Clément Hoguin, Célia Chapelle, Junna Yamaguchi, Rubina Cassaca, Lola Zerbib, Sato Magassa, G Morin, Vahid Asnafi, Patrick Villarèse, Sophie Kaltenbach, Sylvie Fraitag, Jean–Paul Duong Van Huyen, Christine Broissand, O. Boccara, V. Soupre, Bernard Bonnotte, Caroline Chopinet, Tristan Mirault, Christophe Legendre, Laurent Guibaud, Guillaume Canaud
Abstract
Alplesib exerts therapeutic effects in a mouse model of lymphatic anomalies and in six patients with lymphatic malformations over 6 months’ treatment.
Topics & Concepts
MedicineLymphatic systemMagnetic resonance imagingLymphangiomaInternal medicineOncologyPathologyRadiologyVascular Malformations and HemangiomasTumors and Oncological CasesHedgehog Signaling Pathway Studies