TRPML1 channels initiate Ca <sup>2+</sup> sparks in vascular smooth muscle cells
Pratish Thakore, Harry A. T. Pritchard, Caoimhín S. Griffin, Evan Yamasaki, Bernard T. Drumm, Conor P. Lane, Kenton M. Sanders, Yumei Feng, Scott Earley
Abstract
Ca 2+ sparks that control arterial contractility and blood pressure require the lysosomal channel TRPML1.
Topics & Concepts
ContractilityVascular smooth muscleBlood pressureChemistryInternal medicineCell biologySmooth muscleEndocrinologyBiologyMedicineCalcium signaling and nucleotide metabolismIon Channels and ReceptorsPlant Stress Responses and Tolerance