HSP70 promotes MLKL polymerization and necroptosis
Andrea N. Johnston, Zhigao Wang
Abstract
Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 (HSP70) to block its function. Importantly, HSP70 promotes MLKL polymerization to activate necroptosis.
Topics & Concepts
NecroptosisCell biologyBiologyHsp70Programmed cell deathChemistryBiochemistryHeat shock proteinApoptosisGeneHeat shock proteins researchCell death mechanisms and regulation