B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-Catalyzed β-Functionalization of Pyrrolidines Using Isatins via Borrowing Hydrogen: Divergent Access to Substituted Pyrrolidines and Pyrroles
Yong Chen, Hai-Lun Wan, Yuan Huang, Song Liu, Feiyi Wang, Cuifen Lu, Junqi Nie, Zuxing Chen, Guichun Yang, Chao Ma
Abstract
-catalyzed redox-neutral β-functionalization of pyrrolidines with isatins. Under transition-metal- and oxidant-free conditions at ambient temperature, a series of pyrrolidines bearing a functionalized exocyclic alkene are accessed in high efficiency through a borrowing hydrogen process. A simple switch to higher reaction temperature in a one-pot procedure also provides access to a diverse array of C(3)-functionalized pyrroles while liberating water and hydrogen gas as the only byproducts.
Topics & Concepts
ChemistryAlkeneSurface modificationCatalysisCombinatorial chemistryHydrogenTransition metalRedoxReaction conditionsOrganic chemistryPhysical chemistryOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods