Dietary Oxalate Intake and Kidney Outcomes
Matteo Bargagli, Maria Clarissa Tio, Sushrut S. Waikar, Pietro Manuel Ferraro
Abstract
Oxalate is both a plant-derived molecule and a terminal toxic metabolite with no known physiological function in humans. It is predominantly eliminated by the kidneys through glomerular filtration and tubular secretion. Regardless of the cause, the increased load of dietary oxalate presented to the kidneys has been linked to different kidney-related conditions and injuries, including calcium oxalate nephrolithiasis, acute and chronic kidney disease. In this paper, we review the current literature on the association between dietary oxalate intake and kidney outcomes.
Topics & Concepts
OxalateKidney stonesCalcium oxalateRenal functionKidneyKidney diseaseMedicineMetaboliteInternal medicineEndocrinologyPhysiologyCalciumUrologyChemistryOrganic chemistryKidney Stones and Urolithiasis TreatmentsPorphyrin Metabolism and DisordersTherapeutic Uses of Natural Elements