PLK1-mediated phosphorylation of β-catenin enhances its stability and transcriptional activity for extracellular matrix remodeling in metastatic NSCLC
Daeun Kim, Sol‐Bi Shin, Chang-Hyeon Kim, Yeo-Bin Kim, Hyun‐Ji Oh, Hyungshin Yim
Abstract
Our findings provide evidence for the critical role of the PLK1/β-catenin/AP-1 axis in metastatic NSCLC, implying that β-catenin and PLK1 may serve as a molecular target and prognostic indicator of the therapeutic response in metastatic NSCLC patients.
Topics & Concepts
Cancer researchCD44CateninEpithelial–mesenchymal transitionPhosphorylationBiologyDownregulation and upregulationKinasePLK1Cell biologyChemistryMetastasisWnt signaling pathwaySignal transductionCancerCellCell cycleGeneBiochemistryGeneticsWnt/β-catenin signaling in development and cancerCancer-related gene regulationCancer Cells and Metastasis