Combined royal jelly 10-hydroxydecanoic acid and aspirin has a synergistic effect against memory deficit and neuroinflammation
Mengmeng You, Kangli Wang, Yongming Pan, Lingchen Tao, Quanxin Ma, Guozhi Zhang, Fuliang Hu
Abstract
assays showed that the combined treatment synergistically inhibited the overactivation of glial cells and decreased the levels of pro-inflammatory mediators. Moreover, 10-HDAA alleviated the adverse effects of aspirin on gastrointestinal injuries and microbiota dysbiosis. The Morris water maze test indicated that neither 10-HDAA nor aspirin effectively improved LPS-induced memory dysfunction, but the combined therapy showed synergistic effects. Altogether, our findings support 10-HDAA and aspirin combinatory therapy as the basis for future therapeutics for AD and other neuroinflammation-related diseases with minimal adverse effects.
Topics & Concepts
AspirinNeuroinflammationPharmacologyMedicineInflammationAdverse effectMorris water navigation taskNitric oxideDownregulation and upregulationPopulationImmunologyChemistryInternal medicineBiochemistryGeneHippocampal formationEnvironmental healthBee Products Chemical AnalysisPharmacological Effects of Natural CompoundsEssential Oils and Antimicrobial Activity