Recent progress in nanotechnology-based drug carriers for celastrol delivery
Ling Guo, Yongping Zhang, Khuloud T. Al‐Jamal
Abstract
The potential pharmacological activities of CLT in cancer, obesity, and inflammatory, auto-immune, and neurodegenerative diseases have been demonstrated in recent years. However, CLT's clinical application is extremely restricted by its low solubility/permeability, poor bioavailability, and potential off-target toxicity. The advent of nanotechnology provides a solution to improve the oral bioavailability, therapeutic effects or tissue-targeting ability of CLT. This review focuses on the most recent advances, improvements, inventions, and updated literature of various nanocarrier systems for CLT.
Topics & Concepts
CelastrolDrug deliveryDrug carrierNanotechnologyDrugImmune systemChemistryPharmacologyMedicineImmunologyMaterials scienceApoptosisBiochemistryNatural Compounds in Disease TreatmentBioactive Compounds and Antitumor AgentsNanoparticle-Based Drug Delivery