C3-Arylation of indoles with aryl ketones <i>via</i> C–C/C–H activations
Ziqiong Guo, Hui Xu, Xing Wang, Zhen-Yu Wang, Biao Ma, Hui‐Xiong Dai
Abstract
palladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good yields. Further introduction of an indole moiety into the natural products desoxyestrone and evodiamine demonstrate the synthetic utility of this protocol.
Topics & Concepts
ArylIndole testChemistryPalladiumCleavage (geology)Ligand (biochemistry)Medicinal chemistryCatalysisStereochemistryCombinatorial chemistryOrganic chemistryMaterials scienceReceptorBiochemistryAlkylComposite materialFracture (geology)Catalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions