Coupling of Heteroaryl Halides with Chlorodifluoroacetamides and Chlorodifluoroacetate by Nickel Catalysis
Dawei Zhang, Xing Gao, Qiao‐Qiao Min, Yu‐Cheng Gu, Guillaume Berthon, Xingang Zhang
Abstract
Abstract A nickel‐catalyzed cross‐coupling of heteroaryl halides with chlorodifluoroacetamides and chlorodifluoroacetate has been developed. The combination of NiCl 2 ⋅ DME with 4,4′‐diNon‐bpy, co‐ligand PPh 3 , and additive LiCl renders the catalytic system efficient for the synthesis of medicinal interest heteroaryldifluoroacetamides. The application of the method leads to short and highly efficient synthesis of biologically active molecules, providing a facile route for applications in medicinal chemistry and agrochemistry.
Topics & Concepts
HalideNickelCatalysisCombinatorial chemistryLigand (biochemistry)Coupling (piping)ChemistryMoleculeMaterials scienceOrganic chemistryMetallurgyBiochemistryReceptorFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions