Target identification, and optimization of dioxygenated amide derivatives as potent antibacterial agents with FabH inhibitory activity
Hao-Yun Chang, Ruiying Ji, Zhiyu Zhu, Yapin Wang, Yan Shaopeng, Dan He, Qike Jia, Peng Huang, Tao Cheng, Rui Wang, Yang Zhou, Yang Zhou
Topics & Concepts
ChemistryAntimicrobialDocking (animal)Lipinski's rule of fiveAmideStereochemistryIn silicoAntibacterial activityBiochemistryIn vivoIC50CytotoxicityDruggabilityEnzymeStructure–activity relationshipLipophilicityBacteriaCombinatorial chemistryIn vitroBiologyOrganic chemistryMedicineGeneBiotechnologyNursingGeneticsClick Chemistry and ApplicationsAntimicrobial Peptides and ActivitiesAntimicrobial agents and applications