6,11-Dioxobenzo[<i>f</i>]pyrido[1,2-<i>a</i>]indoles Kill <i>Mycobacterium tuberculosis</i> by Targeting Iron–Sulfur Protein Rv0338c (IspQ), A Putative Redox Sensor
Rita Székely, Rengifo-Gonzalez Monica, Vinayak Singh, Olga Riabova, Andrej Benjak, Jérémie Piton, Mena Cimino, Étienne Kornobis, Valerie Mizrahi, Kai Johnsson, Giulia Manina, Vadim Makarov, Stewart T. Cole
Abstract
to two different DBPI; this revealed strong upregulation of the redox-sensitive SigK regulon and genes induced by oxidative and thiol-stress. The findings of this investigation pharmacologically validate a novel target in tubercle bacilli and open a new vista for tuberculosis drug discovery.
Topics & Concepts
Mycobacterium tuberculosisRegulonComplementationMutantMycobacterium marinumBiologyAntimycobacterialTransmembrane domainBiochemistryMycobacteriumGeneMicrobiologyTuberculosisGeneticsBacteriaMedicinePathologyTuberculosis Research and EpidemiologyPneumocystis jirovecii pneumonia detection and treatmentBiochemical and Molecular Research