pH-Activatable copper-axitinib coordinated multifunctional nanoparticles for synergistic chemo-chemodynamic therapy against aggressive cancers
Muse Ji, Hongbing Liu, Hanxun Wang, Xinxin Liang, Mingli Wei, Dongmei Shi, Jingxin Gou, Tian Yin, Haibing He, Xing Tang, Yu Zhang
Abstract
studies assessing cytotoxicity and apoptosis confirmed the superior tumor cell-killing efficacy of the Cu-AXB NPs. This enhanced efficacy can be attributed to the synergistic effect of CDT and chemotherapy. Moreover, the Cu-AXB NPs exhibited excellent tumor targeting capabilities, resulting in significant tumor inhibition (77.53% inhibition) while maintaining favorable biocompatibility in tumor-bearing mice. In conclusion, this study presents a promising and safe strategy for cancer therapy by combining CDT with chemotherapy, offering a potential breakthrough in the field of oncology.
Topics & Concepts
ChemistryHydrogen peroxideCytotoxicityGlutathioneBiocompatibilityNanoparticleIn vitroTumor microenvironmentDrugApoptosisCancer researchBiophysicsCombinatorial chemistryPharmacologyTumor cellsBiochemistryNanotechnologyMaterials scienceOrganic chemistryMedicineEnzymeBiologyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryCancer, Hypoxia, and Metabolism