MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer
Jialin Shang, Shaobo Ning, Ying‐Yi Chen, Tianxiang Chen, Jian Zhang
Topics & Concepts
Cancer researchCell growthSirtuinMAPK/ERK pathwayBiologyPharmacologyCell cycle checkpointKinaseChemistryCell cycleAcetylationCellCell biologyBiochemistryGeneSirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyBioactive natural compounds