The ERG1 K+ Channel and Its Role in Neuronal Health and Disease
Francisco G. Sanchez-Conde, Eric N. Jiménez‐Vázquez, David S. Auerbach, David K. Jones
Abstract
, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered.
Topics & Concepts
NeurosciencePotassium channelPathophysiologyBiologyRegulatorPremovement neuronal activityMedicineEndocrinologyGeneBiochemistryCardiac electrophysiology and arrhythmiasIon channel regulation and functionNeuroscience and Neuropharmacology Research