Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis
Qian Xia, Meng Mao, Zhen Zeng, Zhenzhao Luo, Yin Zhao, Jing Shi, Xing Li
Abstract
Taken together, the results of this study identified a previously unidentified function of SENP6 in neuronal apoptosis and strongly indicated that SENP6 inhibition may provide therapeutic benefits for cerebral ischemia.
Topics & Concepts
SUMO proteinApoptosisAnnexinTUNEL assayAnnexin A1Cell biologyIschemiaChemistryMolecular biologyPharmacologyBiologyBiochemistryMedicineInternal medicineUbiquitinGeneS100 Proteins and AnnexinsUbiquitin and proteasome pathwaysHeat shock proteins research