Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy
Adria Hasan, Ejazul Haque, Rohil Hameed, Paul N. Maier, Safia Obaidur Rab, Mohd Kamil, Aamir Nazir, Snober S. Mir
Topics & Concepts
AutophagyApoptosisA549 cellPI3K/AKT/mTOR pathwayHsp90Downregulation and upregulationHsp90 inhibitorBiologyProtein kinase BCell biologyCancer researchMolecular biologyHeat shock proteinBiochemistryGeneHeat shock proteins researchAutophagy in Disease and TherapyAldose Reductase and Taurine