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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling

Keith Graham, Philip Lienau, Benjamin Bader, Stefan Prechtl, Jan Naujoks, Ralf Lesche, Joerg Weiske, Julia Kuehnlenz, Krzysztof Brzezinka, Lisette Potze, Francesca Zanconato, Barbara Nicke, Anna Montebaur, Wilhelm Bone, Sven Golfier, Stefan Kaulfuß, Charlotte Kopitz, Sabine Pilari, H. Steuber, Sikander Hayat, Atanas Kamburov, Andreas Steffen, Andreas Schlicker, Philipp Buchgraber, Nico Braeuer, Núria Aiguabella Font, Tobias Heinrich, Lara Kuhnke, Katrin Nowak‐Reppel, Carlo Stresemann, Patrick Steigemann, Annette O. Walter, Simona Blotta, Matthias Ocker, Ashley M. Lakner, Franz von Nussbaum, Dominik Mumberg, Knut Eis, Stefano Piccolo, Martin Lange

2024Cell chemical biology11 citationsDOI

Topics & Concepts

YAP1In vivoCell biologyBlockadeSmall GTPaseChemistryCancer researchEffectorHippo signaling pathwayGTPaseSignal transductionSmall moleculeBiologyBiochemistryReceptorTranscription factorGeneBiotechnologyHippo pathway signaling and YAP/TAZPlant Surface Properties and Treatments
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling | Litcius