The anti-breast cancer activity of indeno[1,2-b]pyridin-5-one and their hydrazonal precursors endowed with anti-CDK-2 enzyme activity
Sami A. Al‐Hussain, Thoraya A. Farghaly, Mona H. Ibrahim, Mariam A. Al‐Sheikh, Magdi E. A. Zaki, Zeinab A. Muhammad, Refaie M. Kassab
Topics & Concepts
ChemistryDruggabilityStereochemistryApoptosisEnzymeStructure–activity relationshipCell cycleAnnexinPotencyCytotoxicityCyclin-dependent kinaseIntrinsic apoptosisCytotoxic T cellProgrammed cell deathBiochemistryIn vitroCaspaseGeneCancer therapeutics and mechanismsBioactive Compounds and Antitumor AgentsSynthesis and biological activity