Building a Synthetic Cell Together
Simone Giaveri, Zhanar Abil, Shunshi Kohyama, Min Fu, Antoine Lévrier, Katarzyna P. Adamala, Wachirawit Chinantuya, Cees Dekker, Nan‐Nan Deng, Julius Fredens, Kouichi Hagino, Kevin Jahnke, Xuefei Li, Ariel B. Lindner, Chenli Liu, S. Majumder, Vincent Noireaux, Petra Schwille, Isabella Nymann Westensee
Abstract
Synthetic cells (SynCells) are artificial constructs designed to mimic cellular functions, offering insights into fundamental biology, as well as promising impact in the fields of medicine, biotechnology, and bioengineering. Achieving a functional SynCell from the bottom up, i.e. by assembling it from molecular components, requires a global collaboration to overcome the many challenges of engineering and assembling life-like modules while addressing biosafety, equity, and ethical concerns in order to guide responsible innovation. Here, we highlight major scientific hurdles, such as the integration of functional modules by ensuring compatibility across diverse synthetic subsystems, and we propose strategies to advance the field. Synthetic cells are artificial constructs designed to mimic cellular functions, offering insights into fundamental biology, as well as promising impact in the fields of medicine, biotechnology, and bioengineering. In this perspective, the authors highlight major scientific hurdles, such as the integration of functional modules by ensuring compatibility across diverse synthetic subsystems, and propose strategies to advance the field.