Application of singlet oxygen-activatable nanocarriers to boost X-ray-induced photodynamic therapy and cascaded ferroptosis for breast cancer treatment
Bei-bei Zhang, Hao Liu, Yifei Wang, Yong Zhang, Jingliang Cheng
Abstract
The D-NP VR self-assembled using singlet oxygen-responsive hyperbranched copolymers realized X-ray-boosted release of the ferroptotic inducer, leading to the combined treatment of X-PDT and ferroptosis against breast cancer.
Topics & Concepts
NanocarriersPhotosensitizerSinglet oxygenPhotodynamic therapyGlutathioneChemistryGPX4Reactive oxygen speciesLipid peroxideCancer researchApoptosisBiophysicsBiochemistryPhotochemistryLipid peroxidationOxidative stressDrug deliveryOxygenBiologyOrganic chemistryEnzymeGlutathione peroxidaseNanoplatforms for cancer theranosticsFerroptosis and cancer prognosisEicosanoids and Hypertension Pharmacology