Terpenoids from <i>Resina Commiphora</i> Regulating Lipid Metabolism via Activating PPARα and CPT1 Expression
Si-Si Zhu, Jia-Wang Liu, Yong‐Ming Yan, Ying Liu, Zhuo Mao, Yong‐Xian Cheng
Abstract
Commiphoranoids A–E (1–5), five novel sesquiterpenoids, dinorditerpenoids, and heterodimers with unprecedented carbon skeletons, were isolated from Resina Commiphora. The structure of 1 was secured by X-ray crystallography. Compound 4 represents the first example of C38 terpenoids, whereas 5 is a C30 terpenoid formed by two types of sesquiterpenoids. These metabolites possess lipid regulatory activities via activating PPARα and CPT1.
Topics & Concepts
TerpenoidChemistryLipid metabolismStereochemistryPeroxisome proliferator-activated receptorMetabolismBiochemistryReceptorPharmacological Effects of Medicinal PlantsBone Metabolism and DiseasesTrace Elements in Health