General electrochemical Minisci alkylation of <i>N</i>-heteroarenes with alkyl halides
Roberto del Río‐Rodríguez, Lorena Fragoso-Jarillo, Alberto F. Garrido‐Castro, M. Maestro, José A. Fernández‐Salas, José Alemán
Abstract
-heteroarenes. The method presents a very high functional group tolerance, including various heterocyclic-based natural products, which highlights the robustness of the methodology. This applicability has been further proved in the synthesis of various interesting biologically valuable building blocks. In addition, we have proposed a mechanism based on different proofs and pieces of electrochemical evidence.
Topics & Concepts
HalideAlkylAlkylationElectrochemistryCombinatorial chemistryChemistryRadicalEnvironmentally friendlyOrganic chemistryCatalysisElectrodeBiologyPhysical chemistryEcologyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques