Rapid access to 3-aminoindazoles from nitriles with hydrazines: a strategy to overcome the basicity barrier imparted by hydrazines
Chunyan Zhang, Haowen Zhao, Zehua Li, Zuyu Liang, Shuo Qi, Mingyu Cai, Sheng Zhang, Xiaofei Jia, Guoying Zhang, Mao‐Lin Hu
Abstract
A practical and efficient base mediated synthesis of free 3-aminoindazoles has been developed from the reaction of nitriles with hydrazines, which successfully overcomes the difficulty of using aromatic hydrazines as substrates and allows for the synthesis of a wide range of N-aryl substituted free 3-aminoindazoles in moderate to excellent yields under mild conditions in one-pot. This finding provides a rapid and useful strategy for the synthesis of various functionalized 3-aminoindazole derivatives.
Topics & Concepts
ChemistryCombinatorial chemistryArylReaction conditionsBase (topology)Organic chemistryCatalysisMathematicsAlkylMathematical analysisCatalytic C–H Functionalization MethodsClick Chemistry and ApplicationsChemical Synthesis and Analysis