Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C
Joseph C. Roney, Sunan Li, Tamar Farfel‐Becker, Ning Huang, Tao Sun, Yuxiang Xie, Xiu‐Tang Cheng, Mei-Yao Lin, Frances M. Platt, Zu‐Hang Sheng
Topics & Concepts
LysosomeAutophagyBiologyCell biologyNiemann–Pick diseaseTFEBEndocytic cycleNiemann–Pick disease, type CAutophagosomeAxoplasmic transportLysosomal storage diseaseNeuroscienceEndocytosisCellBiochemistryCholesterolEnzymeApoptosisLysosomal Storage Disorders ResearchAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism