Perinatal low-dose PBDE-47 exposure hampered thyroglobulin turnover and induced thyroid cell apoptosis by triggering ER stress and lysosomal destabilization contributing to thyroid toxicity in adult female rats
Pei Li, Hui Gao, Lixin Dong, Luming Liu, Guoyu Zhou, Chen Luo, Zhiyuan Tian, Tao Xia, Aiguo Wang, Shun Zhang
Topics & Concepts
EndocrinologyThyroglobulinInternal medicineUnfolded protein responseThyroidApoptosisEndoplasmic reticulumCathepsin BToxicityChemistryCathepsin DBiologyMedicineBiochemistryEnzymeEndoplasmic Reticulum Stress and DiseaseHeme Oxygenase-1 and Carbon MonoxideErythrocyte Function and Pathophysiology