Similarities between COVID-19 and anti-MDA5 syndrome: what can we learn for better care?
Margherita Giannini, Mickaël Ohana, Benoît Nespola, Giovanni Zanframundo, Bernard Gény, Alain Meyer
Abstract
As yet, no direct-acting antiviral drugs have demonstrated efficacy in the disease. In contrast, increasing evidence indicates an immune-mediated pathophysiology that is paving the way for the evaluation of immunomodulation strategies [2]. In support of this view, we would like to highlight the striking similarities between COVID-19 and a rare autoimmune disease: the anti-MDA5-syndrome. Similarities between COVID-19 and anti-MDA5 syndrome support further evaluation of employing an immunomodulatory strategy in COVID-19 <https://bit.ly/3dN6lJ8> We thank Pragnell Babette for her English support.
Topics & Concepts
MDA5Coronavirus disease 2019 (COVID-19)MedicineDiseaseImmune system2019-20 coronavirus outbreakIntensive care medicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Contrast (vision)ImmunologyVirologyInternal medicineInfectious disease (medical specialty)RNAArtificial intelligenceComputer scienceOutbreakBiologyGeneticsRNA interferenceGeneImmunodeficiency and Autoimmune DisordersDiabetes and associated disordersInflammatory Myopathies and Dermatomyositis