Sialidase of <i>Glaesserella parasuis</i> Augments Inflammatory Response via Desialylation and Abrogation of Negative Regulation of Siglec-5
Yuping Song, Qicong Pan, Jing Xiao, Wenjie Li, Hui Ma, Huanchun Chen, Xuwang Cai, Xiaojuan Xu
Abstract
Siglecs are sialic acid-binding immunoglobulin-like lectins that play an important role in tissue homeostasis, immune response, and pathogen infection. Bacterial sialidases act on natural ligands of Siglecs, interfering with the Siglec-mediated immune response. Glaesserella parasuis is a porcine bacterial pathogen that secretes sialidase.
Topics & Concepts
SialidaseSIGLECBiologySialic acidImmune systemPathogenMicrobiologyAntibodyN-Acetylneuraminic acidGlycoproteinImmunologyNeuraminidaseBiochemistryVirusGlycosylation and Glycoproteins ResearchMicrobial infections and disease researchGenomics and Phylogenetic Studies