Targeting leukemia-specific dependence on the de novo purine synthesis pathway
Takuji Yamauchi, Kohta Miyawaki, Yuichiro Semba, Masatomo Takahashi, Yoshihiro Izumi, Jumpei Nogami, Fumihiko Nakao, Takeshi Sugio, Kensuke Sasaki, Luca Pinello, Daniel E. Bauer, Takeshi Bamba, Koichi Akashi, Takahiro Maeda
Topics & Concepts
Myeloid leukemiaLeukemiaCRISPRCancer researchBiologyEffectorSmall hairpin RNAPurine analogueCell culturePurineGeneImmunologyEnzymeGeneticsBiochemistryGene knockdownCRISPR and Genetic EngineeringBiochemical and Molecular ResearchAdvanced biosensing and bioanalysis techniques