Palmitoylated antigens for the induction of anti-tumor CD8+ T cells and enhanced tumor recognition
Dorian A. Stolk, Sophie K. Horrevorts, Sjoerd Schetters, Laura Kruijssen, Sanne Duinkerken, Eelco D. Keuning, Martino Ambrosini, Hakan Kalay, Rieneke van de Ven, Juan J. García‐Vallejo, Tanja D. de Gruijl, Sandra J. van Vliet, Yvette van Kooyk
Abstract
tumor suppression of mono-palmitic acid-modified (C16:0) antigenic peptides, which can be attributed to their unique processing route, efficient receptor-independent integration within lipid bilayers, and continuous intracellular accumulation and presentation through MHC class I. We propose that this membrane-integrating feature of palmitoylated peptides can be exploited as a tool for quick and efficient antigen enrichment and MHC class I loading. Importantly, both DCs and non-professional antigen-presenting cells (APCs), similar to tumor cells, facilitate anti-tumor immunity by efficient CTL priming via DCs and effective recognition of tumors through enhanced presentation of antigens.