Cobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy
Sk. Abdus Samim, B. Roy, Sourav Nayak, Sabuj Kundu
Abstract
A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using an aliphatic alcohol–water system. For this transformation, a cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. The substrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol.
Topics & Concepts
TandemCobaltCatalysisLigand (biochemistry)Substrate (aquarium)Transformation (genetics)ChemistryCombinatorial chemistrySalt (chemistry)Scope (computer science)Materials scienceOrganic chemistryComputer scienceBiochemistryReceptorGeneOceanographyProgramming languageGeologyComposite materialQuinazolinone synthesis and applicationsAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods