Metal‐Free Nitration/Cyclization of Unactivated Olefins to Access Nitroated Tetrahydropyridazines with Sodium Nitrate
Xian Liu, Liqiang Hao, Xiao Yu, Shengkui Jin, Yiping Liu, Yafei Ji
Abstract
A metal‐free radical cascade nitration/cyclization reaction of N ‐homoallylacetohydrazides with sodium nitrite is developed for the synthesis of nitroated tetrahydropyridazines. This protocol features readily available raw material, convenient operation, and good functional group tolerance, providing 36 compounds in acceptable yields.
Topics & Concepts
NitrationChemistrySodium nitriteSodium nitrateNitrateFunctional groupOrganic chemistrySodiumRaw materialCascadeCombinatorial chemistryChromatographyPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions