ACE2 mouse models: a toolbox for cardiovascular and pulmonary research
Hongpeng Jia, Xinping Yue, Eric Lazartigues
Abstract
Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. ACE2 is a regulatory enzyme of the renin-angiotensin system and has protective functions in many cardiovascular, pulmonary and metabolic diseases. This review summarizes available murine models with systemic or organ-specific deletion of ACE2, or with overexpression of murine or human ACE2. The purpose of this review is to provide researchers with the genetic tools available for further understanding of ACE2 biology and for the investigation of ACE2 in the pathogenesis and treatment of COVID-19.
Topics & Concepts
Angiotensin-converting enzyme 2Peptidyl-Dipeptidase ACoronavirus disease 2019 (COVID-19)PandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Renin–angiotensin system2019-20 coronavirus outbreakCoronavirusMedicinePathogenesisBiologyReceptorBioinformaticsVirologyComputational biologyImmunologyGeneticsInternal medicineDiseaseInfectious disease (medical specialty)Blood pressureOutbreakRenin-Angiotensin System StudiesCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research