A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation
Michael Dolton, Po‐Chang Chiang, Fang Ma, Jin Y. Jin, Yuan Chen
Topics & Concepts
ChemistryPhysiologically based pharmacokinetic modellingPharmacokineticsBioavailabilityVismodegibAbsorption (acoustics)LipophilicitySolubilityPharmacologyBiophysicsBiochemistryMedicineMaterials scienceHedgehogPhysical chemistryGeneBiologyComposite materialHedgehog Signaling Pathway StudiesOral and gingival health research