Insertion Sequences Determine Plasmid Adaptation to New Bacterial Hosts
Emilia Wedel, Cristina Bernabe-Balas, Manuel Ares-Arroyo, Natalia Montero, Alfonso Santos-López, Didier Mazel, Bruno González‐Zorn
Abstract
ColE1-like plasmids are small, mobilizable plasmids that can be found across at least four orders of Gammaproteobacteria and are strongly associated with antimicrobial resistance genes. Plasmid pB1000 carries the gene bla ROB-1 , conferring high-level resistance to penicillins and cefaclor. pB1000 has been described in various species of the family Pasteurellaceae , for example, in Haemophilus influenzae , which can cause diseases such as otitis media, meningitis, and pneumonia.
Topics & Concepts
PlasmidAdaptation (eye)BiologyComputational biologyMicrobiologyGeneticsGeneNeuroscienceBacteriophages and microbial interactionsEvolution and Genetic DynamicsBacterial Genetics and Biotechnology