Palladium-Catalyzed Fluoroarylation of <i>gem</i>-Difluoroenynes to Access Trisubstituted Trifluoromethyl Allenes
Shutao Qi, Shiquan Gao, Xiaoxiao Xie, Junfeng Yang, Junliang Zhang
Abstract
-difluoroenynes lags much behind. Herein is reported the fluoroarylation of 1,1-difluoro-1,3-enynes with aryl halides in the presence of silver fluoride affording trisubstituted trifluoromethyl allenes under the catalysis of palladium. The reaction features mild conditions, high functional-group tolerance, and high regioselectivity.
Topics & Concepts
ChemistryTrifluoromethylPalladiumRegioselectivityCatalysisArylHalideFluorideFunctional groupCombinatorial chemistryMedicinal chemistryOrganic chemistryInorganic chemistryPolymerAlkylFluorine in Organic ChemistryCatalytic C–H Functionalization Methods