Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens
Yuan Liu, Yuqian Jia, Kangni Yang, Ziwen Tong, Jingru Shi, Ruichao Li, Xia Xiao, Wenkai Ren, Rüdiger Hardeland, Rüssel J. Reiter, Zhiqiang Wang
Abstract
Our findings revealed that melatonin serves as a promising colistin adjuvant against MCR-positive Gram-negative pathogens.
Topics & Concepts
ColistinAntibioticsEffluxMelatoninMicrobiologyIn vivoBiologyPharmacologyMembrane permeabilityPolymyxinGram-negative bacteriaMedicineEscherichia coliBiotechnologyBiochemistryGeneMembraneNeuroscienceAntibiotic Resistance in BacteriaGut microbiota and healthCircadian rhythm and melatonin