Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer’s disease
Xueyang Jiang, Junting Zhou, Yang Wang, Lei Chen, Yan Duan, Jianping Huang, Chang Liu, Yao Chen, Wenyuan Liu, Haopeng Sun, Feng Feng, Wei Qu
Topics & Concepts
ChemistryCholinesteraseClass (philosophy)Rational designDual (grammatical number)ButyrylcholinesteraseAlzheimer's diseaseDiseaseDegenerative diseasePharmacologyEnzymeAcetylcholinesteraseNeuroscienceBiochemistryCentral nervous system diseaseNanotechnologyAchéInternal medicinePsychologyEpistemologyMaterials scienceMedicineArtLiteraturePhilosophyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity