Native Amide‐Directed C(sp<sup>3</sup>)−H Amidation Enabled by Electron‐Deficient Rh<sup>III</sup> Catalyst and Electron‐Deficient 2‐Pyridone Ligand
Takumi Wakikawa, Daichi Sekine, Yuta Murata, Youka Bunno, M. Kojima, Yuki Nagashima, Ken Tanaka, Ken Tanaka, Tatsuhiko Yoshino, Tatsuhiko Yoshino, Shigeki Matsunaga
Abstract
Abstract Trivalent group‐9 metal catalysts with a cyclopentadienyl‐type ligand (CpM III ; M=Co, Rh, Ir, Cp=cyclopentadienyl) have been widely used for directed C−H functionalizations, albeit that their application to challenging C(sp 3 )−H functionalizations suffers from the limitations of the available directing groups. In this report, we describe directed C(sp 3 )−H amidation reactions of simple amide substrates with a variety of substituents. The combination of an electron‐deficient Cp E Rh catalyst (Cp E =1,3‐bis(ethoxycarbonyl)‐substituted Cp) and an electron‐deficient 2‐pyridone ligand is essential for high reactivity.