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Novel α-Aminophosphonates of imatinib Intermediate: Synthesis, anticancer Activity, human Abl tyrosine kinase Inhibition, ADME and toxicity prediction

Saikiran Aita, Vishnu Nayak Badavath, Mohan Gundluru, Murali Sudileti, Bakthavatchala Reddy Nemallapudi, G. Sravya, G. V. Zyryanov, Naga Raju Chamarti, Suresh Reddy Cirandur

2021Bioorganic Chemistry28 citationsDOI

Topics & Concepts

ChemistryADMEIC50ImatinibCytotoxicityMTT assayDoxorubicinTyrosine kinasePharmacologyIn vitroStereochemistryCombinatorial chemistryBiochemistryCancer researchMedicineChemotherapySignal transductionSurgeryMyeloid leukemiaBiologyChronic Myeloid Leukemia TreatmentsFungal Plant Pathogen ControlSynthesis and biological activity
Novel α-Aminophosphonates of imatinib Intermediate: Synthesis, anticancer Activity, human Abl tyrosine kinase Inhibition, ADME and toxicity prediction | Litcius