Visible-Light-Driven Synergistic Se/Fe Catalysis for the Synthesis of 2-Aminoquinoline Derivatives
Yan‐Ling Ji, Hong Wang, Xiang‐Hong He, Junchao Zhu, Cheng Peng, Qian Zhao, Gu Zhan, Bo Han
Abstract
A visible-light-driven Se/Fe synergistic catalytic reaction between isocyanides and amines has been developed, employing air as the terminal oxidant. This efficient strategy offers facile access to 2-aminoquinoline scaffolds. The use of cost-effective and readily available Fe(OTf) 3 modulates the selenium catalyst’s oxidation state, enhancing the method’s environmental friendliness and practicality. The protocol is further distinguished by its good yields, broad substrate scope, and mild reaction conditions.
Topics & Concepts
ChemistryCatalysisCombinatorial chemistrySynergistic catalysisVisible spectrumOrganic chemistryPhysicsOptoelectronicsSulfur-Based Synthesis TechniquesOrganoselenium and organotellurium chemistryRadical Photochemical Reactions