Design, synthesis, biological evaluation and molecular modelling studies of oxoacetamide warhead containing indole-quinazolinone based novel hybrid analogues as potential pancreatic lipase inhibitors
Prashant S. Auti, Arijit Nandi, Vijeta Kumari, Atish T. Paul
Abstract
A novel series of indolyl oxoacetamide-quinazolinone hybrid analogues (9aa–9df) were designed, synthesized, and evaluated for their in vitro pancreatic lipase (PL) inhibitory potential that may lead to efficient anti-obesity agents.
Topics & Concepts
ChemistryQuinazolinoneLipasePancreatic lipaseIndole testIn vitroBiochemistryCombinatorial chemistryEnzymeQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationCannabis and Cannabinoid Research