Discovery of Thieno[3,2-d]pyrimidine derivatives as potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) kinase
Yunxin Duan, Haodong Cheng, Lili Zhuang, Jiawei Xia, Yerong Xu, Ruyue Zhang, Rui Sun, Tao Lu, Yadong Chen
Topics & Concepts
ChemistryKinaseDNA damagePyrimidineLead compoundIn vivoCHEK1PharmacologyBiochemistryIn vitroDNACell cycle checkpointCell cycleBiologyCellGeneticsDNA Repair MechanismsPARP inhibition in cancer therapyCell death mechanisms and regulation