Effect of soybean peptides against hydrogen peroxide induced oxidative stress in HepG2 cells<i>via</i>Nrf2 signaling
Guofu Yi, Jalal Ud Din, Fen Zhao, Xinqi Liu
Abstract
), malondialdehyde (MDA) and oxidized glutathione (GSSG) in HepG2 cells. Moreover, they also prevented the reduction of reduced glutathione (GSH) and up-regulated cellular resistance oxidase activity. In addition, soybean peptide treatment stimulated the mRNA and protein expression levels of antioxidant enzymes and nuclear factor erythroid-2-related factor 2 (Nrf2). Activated Nrf2 up-regulated antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px)) and inhibited ROS and MDA production. It was concluded that soybean peptides effectively activated the Nrf2/antioxidant response element (ARE) mediated activity.
Topics & Concepts
Oxidative stressHydrogen peroxideIntracellularAntioxidantChemistryHydrolysateBiochemistryOxidative damageSignal transductionCell biologyBiologyHydrolysisProtein Hydrolysis and Bioactive PeptidesBiochemical effects in animalsGDF15 and Related Biomarkers