Antimicrobial efficacy of a nitric oxide-releasing ampicillin conjugate catheter lock solution on clinically-isolated antibiotic-resistant bacteria
Manjyot Kaur Chug, Lauren Griffin, Mark Garren, Emma Tharp, Grace H. Nguyen, Hitesh Handa, Elizabeth J. Brisbois
Abstract
hemolysis and cell compatibility studies. Together, these results emphasize the promising potential of SNAPicillin lock solution with the dual-action of NO and ampicillin in overcoming bacterial challenges on medical devices like central venous catheters and other medical device interfaces.
Topics & Concepts
AntimicrobialAmpicillinAntibioticsBacteriaMicrobiologyNitric oxideChemistryConjugateCatheterGram-negative bacteriaLock (firearm)MedicineBiologyBiochemistryEscherichia coliSurgeryOrganic chemistryMathematical analysisEngineeringMechanical engineeringGeneticsGeneMathematicsCentral Venous Catheters and HemodialysisAntibiotics Pharmacokinetics and EfficacyInfective Endocarditis Diagnosis and Management