Treatment options for progression or recurrence of glioblastoma: a network meta-analysis
McBain, C, Lawrie, TA, Rogozińska, E, Kernohan, A, Robinson, T, Jefferies, S
2021UCL Discovery (University College London)111 citations
Abstract
For treatment of first recurrence of GBM, among people previously treated with surgery and standard chemoradiotherapy, the combination treatments evaluated did not improve overall survival compared with LOM monotherapy and were often associated with a higher risk of severe adverse events. Limited evidence suggested that re‐operation with or without re‐irradiation and chemotherapy may be suitable for selected candidates. Evidence on second recurrence is sparse. Re‐irradiation with or without bevacizumab may be of value in selected individuals, but more evidence is needed.
Topics & Concepts
GlioblastomaMeta-analysisMedicineOncologyInternal medicineComputer scienceCancer researchGlioma Diagnosis and TreatmentRadiomics and Machine Learning in Medical ImagingCancer, Hypoxia, and Metabolism