Controlled oxygen delivery to power tissue regeneration
Elizabeth R. Zoneff, Yi Wang, Colin J. Jackson, Oliver B. Smith, Serena Duchi, Carmine Onofrillo, Brooke L. Farrugia, Simon E. Moulton, Richard J. Williams, Clare L. Parish, David R. Nisbet, Lilith M. Caballero Aguilar
Abstract
Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutions call for novel oxygen delivery systems. To become a reality, these systems must consider physiological processes, oxygen release mechanisms and the target application. In this review, we explore the biological relevance of oxygen at both a cellular and tissue level, and the importance of its controlled delivery via engineered biomaterials and devices. Recent advances and upcoming trends in the field are also discussed with a focus on tissue-engineered constructs that could meet metabolic demands to facilitate regeneration.