A real-time in vivo clearance assay for quantification of glymphatic efflux
Virginia Plá, Peter A. R. Bork, Aurakoch Harnpramukkul, Genaro E. Olveda, Antonio Ladrón-de-Guevara, Michael Giannetto, Rashad Hussain, Wei Wang, Douglas H. Kelley, Lauren M. Hablitz, Maiken Nedergaard
Abstract
= 240 min), in wild-type mice. This in vivo methodology will aid in defining the physiological variables that drive efflux, as well as the impact of brain states or disorders on clearance kinetics.
Topics & Concepts
EffluxGlymphatic systemKineticsIn vivoChemistryBiophysicsCompartment (ship)BiochemistryCerebrospinal fluidBiologyNeuroscienceOceanographyBiotechnologyGeologyQuantum mechanicsPhysicsCerebrospinal fluid and hydrocephalusNeonatal and fetal brain pathologyTraumatic Brain Injury and Neurovascular Disturbances